Given the influence of mTOR in the growth of benign and malignant cerebral tumors associated with NF1 and the role of constitutively active 5-HT6 receptors in the enhanced cerebral mTOR activity in Nf1+/− mice, the impact of 5-HT6 receptor inverse agonists on NF1-associated tumors certainly warrants further exploration. The gene discussed is NF1; the disease is neoplasm of cerebral hemisphere.