Moreover, He et al. (2015) identified a positive correlation between the protein levels of phosphorylated VCP and Aurora-B in osteosarcoma tissues using immunohistochemistry; Aurora-B knockdown suppresses the phosphorylation of VCP, NF-κB activity, and the malignant phenotype of osteosarcoma cells (U2-OS and HOS) [92]. This evidence concerns the gene AURKB and osteosarcoma.