THBS1 and colonic neoplasm: In addition, Her et al. identified thrombospondin-1 (THBS1) as a CB-5083-upregulated gene involved in HCT116 colon cancer cell resistance to CB-5083, and THBS1 blockade sensitized cells to CB-5083-mediated growth inhibition and induced an increase in a sub-G1 population and caspase 3/7 activity [141].