In the same year, other authors observed that the balance of HDAC6-VCP/p97 (increasedHDAC6levels and decreased VCP/p97 levels) was positively associated with temozolomide resistance in glioblastoma and that the reversal of the ratio of HDAC6-VCP/p97 represented a potential therapeutic strategy [112]. The gene discussed is HDAC6; the disease is glioblastoma.