VCP and cancer: In addition, these authors reported that PPA exerted antiproliferative effects on colon cancer (HCT116), cervical cancer (HeLa), and multiple myeloma (RPMI8226) cells and inhibited the growth of HCT116 cells resistant to two other inhibitors (CB-5083 and NMS-873), suggesting that PPA is a good candidate to treat cancer and overcome resistance to other VCP/p97 inhibitors [151].