STAT3 and neoplasm: Recently, Yokomizo et al. (2019), using different methods including in vitro, in vivo, and clinical approaches demonstrated that the reduction of tumor-suppressor miR-34a expression is strongly correlated with the pathogenesis of epithelial ovarian cancer inducing the upregulation of IL-6R and the consequent dysregulation of IL-6/STAT3 target genes [42].