A potential link between miRNAs and inflammation was also proposed for cholangiocarcinoma by Lin et al. (2016) that suggested the downregulation of let-7c, miR-99a and miR-125b promoted tumor pathogenesis and progression by targeting IL-6, IL-6R and Insulin-like Growth Factor 1 (IGF1) [41]. This evidence concerns the gene IGF1 and neoplasm.