Several PPAR agonists, for instance, pioglitazone, rosiglitazone, fenofibrate, benzafibrate, and others have been shown to safeguard nerve cells from oxidative stress, inflammation, and programmed cell death in PD and other incapacitating neurodegenerative diseases and are enumerated in this review [10]. This evidence concerns the gene PPARA and neurodegenerative disease.