PRKN and Parkinson disease: In addition, several investigations have reported that mutations in the PARK2 gene are also associated with diminished functioning of the powerhouse of the cell and elevated susceptibility towards substances that are harmful to the powerhouse of the cell, and in the case that the cells’ powerhouse in DArgic nerve cells is disrupted, it could impair the conveyance of DA, potentially contributing to the manifestation of PD [95].