Mutations in genes, such as ubiquitin C-terminal hydrolase L1(UCHL1) [71], α-synuclein(SNCA) [72], leucine-rich repeat kinase 2(LRRK2) [73], Parkin RBR E3 ubiquitin-protein ligase(Parkin) [74], PTEN-induced kinase 1(PINK1) [74], protein deglycase(DJ-1) [75], and glucocerebrosidase(GBA) [76] can result in the development of PD. The gene discussed is PRKN; the disease is Parkinson disease.