Inflammatory processes and programmed cell death in the PD brain are further supported by transformation of activity of pro-apoptotic genes, raised concentrations of a tumor suppressor protein termed p53, NF-κB, interferon gamma (IFNγ), and stimulation of caspases inside the SN region of individuals with PD [144,145,146,147]. Here, NFKB1 is linked to Parkinson disease.