Finally, a recent study analyzed HOTAIR expression in typical carcinoid tumors, atypical carcinoid tumors, small cell lung carcinoma (SCLC/NEC) and large cell neuroendocrine carcinoma (LCNEC/NEC), highlighting its upregulation only in SCLC/NEC patients [59]. Here, HOTAIR is linked to large cell neuroendocrine carcinoma.