LZTS1 and Ehlers-Danlos syndrome, hypermobility type: Again, into a multigenerational Belgian family a heterozygous missense mutation in a chromosomal locus (8p22–8p21.1) of the lzts1 gene was confirmed to be present in all hEDS patients and in none of the unaffected, but its involvement in connective tissue biology is still not clarified and additional research needed to be done in this way [51].