Predominant upregulation of Toll-like receptor pathway regulation genes such as Toll-like receptor 1 (TLR-1), TLR-2, TLR-3, TLR-4, TLR-6, and TLR-8 in obese asthmatics compared with healthy controls could be an additional proof of the potential role of viral infections in the low type-2 obesity asthma phenotype (Figure 3B) [42,43]. This evidence concerns the gene TLR4 and viral infectious disease.