FSHB and primary ovarian failure: Interestingly, mutations in the FSHβ sequence have already been reported as a cause for infertility in males, whereas FSHβ polymorphisms in females seem to affect the basic level of FSH in different ways, affecting the ovarian activity, either due to a positive response to exogenous gonadotropin administration or to alterations of the phenotype in several disfunctions such as PCOS and premature ovarian failure, for example [2,4,43,44,60,61,62,63,64,65,66].