UBE2D3 is a protein-coding gene that encodes UbcH5c, a member of the E2 ubiquitin-conjugating enzyme family, participating in ubiquitination of multiple vital signaling pathways such as p53 tumor-suppressor [31] and NF-κB [32], an essential transcription factor for immune-related genes, and importantly, inflammation [33]. The gene discussed is UBE2D3; the disease is neoplasm.