It promotes axon path finding and nerve regeneration through its interaction with the canonical receptors deleted in colorectal cancer (Dcc) or the homolog neogenin-1 (Neo1) [1], while it acts as a repulsion molecule through the receptors uncoordinated (Unc5b) and Dcc/Unc in nerve regeneration [2]. The gene discussed is NEO1; the disease is colorectal cancer.