Alcohol Dehydrogenase 4 (ADH4) (rs1126670, rs1126671, rs2032349) and Alcohol Dehydrogenase 5 (ADH5) (rs2602836), gene variants in human alcohol dehydrogenase family genes, have been related to AFD progression [66]. The gene discussed is ADH4; the disease is Nager acrofacial dysostosis.