Most of the altered proteins in the mitochondrial disease category (DLD, SLC25A4, NDUFA4, NDUFB5, NDUFB6, NDUFB9, NDUFS1, NDUFA12, UQCRB, CAPN1 and SL25A12) were also found in the group of proteins found to be enriched in energy-related functions (Table 1). This evidence concerns the gene NDUFB5 and mitochondrial disease.