CRISPR/Cas9 technique has been used to model common LOF alterations found in CLL (such as BIRC3, TP53, CHD2, ATM, MGA, SAMHD1) in the murine interleukin 3 (IL-3)-dependent pro-B cell line Ba/F3 [67,68]. This evidence concerns the gene ATM and B-cell chronic lymphocytic leukemia.