IFNG and neoplasm: The pivotal actions of IL-12 are to induce interferon-gamma (IFN-γ) production by natural killer and T cells [11,12,13,14], differentiate naïve CD4+ T cells toward the T helper-1 (Th1) phenotype [15], expand the growth and cytotoxic activity of natural killer and T cells [16], and enhance the antibody-dependent cellular cytotoxicity against tumor cells [17].