IL-12 also modifies the tumor microenvironment via enhancement of MHC class I expression on tumor cells [18,19], polarization of M2 macrophages toward activated M1 macrophages [20], and introduction of an anti-angiogenic effect by inhibiting the proliferation of endothelial cells associated with monokines induced by IFN-γ (MIG) and IFN-γ-inducible protein 10 (IP-10) [21,22]. The gene discussed is IFNG; the disease is neoplasm.