Significantly increased levels of pro-inflammatory cytokines (IL-2, IFN-γ, IL-1β, TNF-α, IL-6, IL-12, and IL-15) and anti-inflammatory cytokines (IL-4, IL-5, and IL-13) in MDD Pts; IFN-γ, IL-1β, TNF-α, IL-6, IL-12, and IL-15 decreased only at week 4; increased IL-2 only at week 8; increased anti-inflammatory cytokines IL-4 and IL-5 at week 8. Here, IL1B is linked to major depressive disorder.