In pathological obesity, adipocytes are enlarged and there is an increased secretion of TNF-α and plasminogen activator inhibitor-1 (PAI-1) [13,105,106], as well as pro-inflammatory chemokines and cytokines: monocyte chemoattractant protein 1, interleukins IL-6 and IL-10. Here, SERPINE1 is linked to obesity due to melanocortin 4 receptor deficiency.