NPM1 and acute myeloid leukemia: The 2016 classification of AML with recurrent genetic abnormalities (Table 1) primarily consists of chromosomal translocations with only two single-gene mutations included, biallelic mutation in the transcription factor gene CCAAT/enhancer binding protein alpha (CEBPA) and AML with a mutated nucleophosmin 1 (NPM1) gene [15].