Recently, three new NPM1 translocations were identified in cases of AML: (i) t(5;10)(q35;q23); (ii) t(5;18)(q34;q12), and (iii) t(5;6)(q35;q23), generating the NPM1/RPP30, NPM1/SETBP1 and NPM1/CCDC28A fusion transcripts [42]. This evidence concerns the gene NPM1 and acute myeloid leukemia.