Recently, it was reported that inhibition of energy production signaling such as PI3K/Akt suppressed epithelial-to-mesenchymal transition in hepatocellular carcinoma through the Snail/GSK-3/beta-catenin pathway, which describes a therapeutic approach to suppress the development of HCC employing energy blockers [29,30,31]. Here, CTNNB1 is linked to hepatocellular carcinoma.