As shown as Figure 4C,D, mRNA levels of MyoD and MYH1 in the gastrocnemius muscle were lower (24% and 33%, respectively) in OM than in YM; oral administration of HY7715 to OM increased the levels of MyoD and MYH1 by 61% and 49%, respectively, of those of observed in YM and was more effective than creatine. The gene discussed is MYOD1; the disease is ocular melanoma.