IL6 and Insulin resistance: Treatment with soluble gp130Fc, in which Fc fusion is an established method used to prolong the half-life by fusing the fragment crystallizable region (Fc) of IgG to recombinant or therapeutic proteins, has demonstrated the blocking of IL-6 trans signaling, unlike complete ablation of IL-6 signaling, and efficacy against HFD-induced macrophage accumulation but no improvement of insulin resistance [121].