Furthermore, SVF from controls were co-cultured in vitro with ILC1 or ILC-depleted CD45+ cells sorted from the SVF of obese T2D patients, and the mRNA expression of Tgfb1, Mincle, inducible nitric oxide synthase (iNOS), and collagen genes, Col1a and Col3a, was increased in the SVF of the ILC non-depleted group. Here, NOS2 is linked to type 2 diabetes mellitus.