ICU non-survivors in this cohort had higher levels of the endothelial dysfunction markers soluble E-selectin (sE-sel), soluble P-selectin (sP-sel), soluble intercellular adhesion molecule 1 (sICAM-1), and angiopoietin 2 (ANG-2) when compared to survivors, as recently reported using a subset of the current Evangelismos cohort samples [33]. The gene discussed is ANGPT2; the disease is endothelial dysfunction.