While no effect on the expression of the anterior segment marker pax6a was observed, it has been shown that pitx2 expression is regulated by Pax6a/b in zebrafish [28] which may contribute to the anterior segment phenotypes (aniridia, Peter’s anomaly) observed in patients and zebrafish with PAX6/pax6 mutations [63]. The gene discussed is PAX6; the disease is aniridia.