Strikingly, IRE1α inhibitors (STF-083010) completely block the splicing of XBP1 (a target of IRE1α) in adipocytes (Figure 5D), and the inhibition of IRE1α by treatment with 4μ8c led to significant remission of ERS (Figure 5E). The gene discussed is ERN1; the disease is amelogenesis imperfecta type 1G.