NR3C2 and cardiac hypertrophy: Activation of the mineralocorticoid receptor (MR) stimulates not only salivary and sweat gland ducts, aldosterone-sensitive distal nephrons and the colon, but also has multiple effects on cardiomyocytes, fibroblasts, podocytes, endothelial cells, and many others [1], which lead to cardiac hypertrophy, fibrosis and proinflammatory effects [1,2].