CD8A and neoplasm: These antibodies specific to tumor antigens, for instance, can recognize cancer cells through their variable regions and mediate tumor killing by phagocytosis (antibody-dependent cell phagocytosis: ADCP), by lysis induced by CD8+ T cells or NK cells (antibody-dependent cell cytotoxicity: ADCC) or by the complement (complement-dependent cytotoxicity: CDC) through their constant regions recognized by Fc receptors expressed on immune cells.