INS and Alzheimer disease: In addition, intracerebroventricular administration of Aβ oligomers causes behavioral changes and AD-like pathology in primates [114], while intracerebral injection of Aβ oligomers results in a range of pathological states, such as inflammation in the hypothalamus, as well as peripheral glucose intolerance, glucose resistance, inflammatory processes in adipose tissue, and disturbances in insulin-induced GLUT 4 translocation into the cell membranes of skeletal muscle [115].