Inhibition of MCP-1 expression with various agents, such as methanolic extract from unripe kiwi fruit (Actinidia deliciosa), dehydroabietic acid, capsaicin, curcumin modulates NFKB1, TNFα, nitric oxide, IL8, and adiponectin resulted in a reduction of DN pathogenesis with a subsequent reduction in tissue damage [95]. Here, TNF is linked to liver dysplastic nodule.