COL15A1 and neoplasm: These observations were followed up by studies showing that the overexpression of full-length ColXV cDNA in human cervical cancer cells (which normally do not express ColXV) significantly inhibits tumour cell growth in soft agar and in vivo without affecting tumour angiogenesis in xenografts; furthermore, the overexpression of the restin domain alone in tumour cells does not inhibit the growth of subcutaneous tumours [24,25].