Thus, in the presence of ColXV, the proper architecture of the collagenous ECM is preserved and the communication between the ECM compartment and the mammary epithelium is appropriately regulated, supporting E-cadherin stabilisation and epithelial polarisation, as reported in a ColXV overexpression model of pancreatic adenocarcinoma [26]. Here, CDH1 is linked to pancreatic adenocarcinoma.