Interestingly, the PRKCA protein was also important for explaining the WNT pathway activity scores in Model 3, with a significant negative regression coefficient (Figure 8), which is in line with the known function of PRKCA, which is to inhibit WNT signalling via several mechanisms, including the phosphorylation of β-catenin, and enhance CRC cell death, concretely fitting to the survival data presented in Figure 5 [47]. Here, PRKCA is linked to colorectal carcinoma.