Although in a sheep model of asthma, a monoclonal antibody called MECA-79 reactive against sulfated sLex showed suppressive effects in both the airway hyperresponsiveness and L-selectin-mediated leukocyte recruitment through ectopically induced HEV-like blood vessels [46], this difference of L-selectin-dependency in the asthma models might be possibly due to the species difference. This evidence concerns the gene SELL and asthma.