Prior research based on L-selectin-deficient mice showed partially decreased airway hyperresponsiveness in a murine model of asthma, but the airway inflammation and leukocyte recruitment were unchanged in the KO mice compared with those in WT mice [45], indicating that L-selectin was not as important as P- and E-selectin in a murine model of allergic asthma. The gene discussed is SELE; the disease is allergic asthma.