To date, some studies have reported that the NLRP3 inflammasome can be activated in response to chronic hyperglycemia [23,24,25,26]; however, little is known about the effect of acute glucose shifts on the activation of the NLRP3 inflammasome in THP-1 cells, given that THP-1 is a human leukemia monocytic cell line extensively used as a model to estimate the modulation of monocyte and macrophage activities [27]. This evidence concerns the gene NLRP3 and leukemia.