Our previous studies showed that certain integrins are controlled directly by tumor-suppressive miRNAs (e.g., miR-29-family, miR-150, and miR-199a) and that the activation of signaling mediated by ITGA3/ITGB1 and ITGA6 enhances the aggressiveness of HNSCC [12,16,25]. Here, ITGA6 is linked to head and neck squamous cell carcinoma.