While there is no clear understanding of the exact point of when TGFβ stops being a tumor suppressor and becomes a tumor promoting factors, studies mainly have shown that it acts at the stromal-epithelial level via three different TGFβ receptors—TGFβ1, TGFβ2, and TGFβ3 present on tumor cells, as well as on nonmalignant stromal cells such as fibroblasts and endothelial cells [58]. This evidence concerns the gene TGFB3 and neoplasm.