ADAM17 and cancer: Taking into account that the only adhesion molecule described to interact in trans with ADAM17 was the integrin α5β1, and also that the α5 chain of this integrin was abundantly expressed on Colo-320 cells (Supplementary Figure S1) but not on exosomes (Figure 2C,D), these results strongly indicate that the Dis domain of exosomal ADAM17 was the ligand being recognized by cellular integrin α5β1 during interactions of exosomes with Colo-320 cancer cells.