HMGB1 and Sepsis: In the present work, we sought to evaluate the actual potential for decision making/outcome prediction of the most commonly proposed chromatin-related biomarkers (i.e., nucleosomes, citrullinated H3, and HMGB1) in a pilot study to differentiate between sepsis and septic shock patients in reference to controls, which included both healthy subjects and, importantly, critically ill nonseptic patients from the ICU who had suffered spontaneous intracerebral hemorrhage.