Regarding determination of HMGB1 levels, and in contrast to the previous results, these were not significantly higher exclusively in septic shock patients; in fact, significance between healthy subjects and sepsis was higher than between healthy subjects and septic shock patients (p < 0.0001 vs. p < 0.001); when comparing ICU controls and both groups of patients, again the highest statistical significance was found between ICU controls and sepsis patients (p < 0.001). The gene discussed is HMGB1; the disease is Sepsis.