Since HMGB1 can be found in differentially oxidized forms and has been reported to influence the activity of endothelial eNOS and ROS pathways [21], studying its presence in the bloodstreams of sepsis patients in relation to the impairment of clinical parameters could provide important clues regarding the regulation of antioxidant response homeostasis and sepsis progression. This evidence concerns the gene HMGB1 and Sepsis.