ITGAM and Stroke: To assess whether thrombin-induced inflammatory processes and the maintenance of the BBB in edoxaban-treated mice have an effect on the invasion of inflammatory cells into the brain parenchyma [15], we determined the number of CD3+ T cells, Ly6b.2+ neutrophils, and CD11b+ macrophages/microglia in the ischemic hemisphere 24 h after stroke induction (Figure 3B–D).