In contrast, expression levels of paraoxonase enzymes 1-3 (Pon1, Pon2, Pon3), which could detoxify oxidated lipids [37] and alleviate angiotensin-II-induced heart failure [38], were unaltered in Tg-SCD hearts (Figure A6a–c). The gene discussed is PON3; the disease is Schnyder corneal dystrophy.