PNLIP and obesity due to melanocortin 4 receptor deficiency: A good alternative may be drugs that act against pancreatic lipase, which is the key enzyme for the absorption of lipids that catalyzes the hydrolysis of triacylglycerols in the gastrointestinal tract; in fact, it is generally thought that a potent and specific inhibitor of pancreatic lipase may be useful in the treatment of obesity [11].