In colorectal cancer cell lines, TNF-α and TGF-β induce EMT-like changes in an NLRP3/Snail1 axis-dependent manner, with Snail being stabilized and protected from degradation in response to TNF-α signaling, helping complete EMT and promote cancer cell migration and metastasis [53,54]. This evidence concerns the gene SNAI1 and colorectal cancer.