IL17A and autoimmune disease: IL-17A and IL-17F have been implicated in a broad spectrum of inflammatory and autoimmune disease—after linking with their receptors—IL-17RA and IL-17RC, both cytokines can induce secretion of pro-inflammatory cytokines, like IL-6, IL-1, IL-8, TNF-α, and chemokine CXCL1, favoring tissue inflammation, the recruitment of neutrophils, activation of innate immune cells and enhancing B cell functions [156].