IL6 and autoimmune disease: For example, IL-12 can induce Th1 response and CD8+ T-cell and NK-cell activation, which are important for combating viral and intracellular pathogens’ infection, whereas IL-6 and IL-23 may direct the immune activity towards a Th17 response, which plays an important role in the recruitment of neutrophils and macrophages, immune responses against fungal infections and in autoimmune diseases [69].