To determine whether our previously identified calcium-target and calcium-regulating signatures of AS can also discriminate Rett syndrome patients, we first studied the dataset generated from cerebellum of Mecp2 knockdown male mice (Mecp2-KO) and their wild-type (WT) controls available in the NCBI database under the accession number GSE105045 [24]. Here, MECP2 is linked to Rett syndrome.