Nobiletin also significantly suppressed the transcriptional analysis of the PD-L1 gene (CD274) expression, which suggested the role of nobiletin in PD-L1 inhibition, suggesting the possible evasion of the immunosuppression ability of nobiletin against A549, H292, and H460 NSCLC cells. The gene discussed is CD274; the disease is non-small cell lung carcinoma.