LRRK2 and Parkinson disease: Besides α-syn, it was demonstrated that miR-205 regulates the expression of LRRK2 contributing to a pathogenic increase of this gene in PD patients [130] and Gehrke et al., (2010) demonstrated a bidirectional regulation between miRNAs and LRRK2, where pathogenic variants of the gene modulated the levels of miR-let-7 and miR-184 [131].