PRKN and Parkinson disease: Recently, a review by Cai and Jeong (2020) [240] highlighted that defects in mitophagy have been widely associated with PD (especially in the PINK1/Parkin pathway but also in others like lipid-mediated mitophagy) and that increased rates of mtDNA deletions have been observed in PD patients, which could be related to dysfunctions in this process of mitochondrial quality control.