From the above, it is easy to foresee that defects in PI3K/AKT signaling pathways can result in serious ovarian dysfunctions such as diminished ovarian reserve (DOR), premature ovarian insufficiency (POI), or premature ovarian failure (POF), and poor ovarian response (POR), characterized by reduced PMF/oocyte survival or defects in follicular activation. Here, AKT1 is linked to primary ovarian failure.