As for the in vivo effects of such innate immune cells in our syngeneic GBM mouse model, CC was observed to cause a suppression of the M2-linked transcription factor STAT-3, induction of the proinflammatory cytokine IL12, and activation of the M1-linked transcription factor STAT-1 in the TAMs and activation of NK cells to cause elimination of GBM (Figure 2) [9,12]. This evidence concerns the gene STAT3 and glioblastoma.