Ph-like ALL is characterized by a spectrum of genetic alterations activating tyrosine kinase (ABL class fusions and involving other rare kinases: NTKR3, BLNK, DGKH, PTK2B, FLT3, FGFR1, and TYK2), cytokine receptor genes (JAK-STAT signaling pathways), and sequence mutations (FLT3, IL7R, and SH2B3 are the most common) [27,42,43]. The gene discussed is ABL1; the disease is acute lymphoblastic leukemia.