The Nppa gene, encoding for the ANP, is involved in regulation of the cAMP signaling pathway and renin–angiotensin system (RAS), while cAMP signaling could ameliorate HTN [43], where the cardiac myocyte cAMP level and the myocardial contractile function are regulated by the phosphodiesterase 3A [44]. This evidence concerns the gene REN and hypertensive disorder.