For instance, TRPM4 and TRPM5 are almost impermeable to Ca2+ (PCa/PNa < 0.01), whereas TRPV1, TRPV4, and TRPA1 present a high Ca2+ permeability (PCa/PNa~6-10) [204,205]. The gene discussed is TRPV4; the disease is posterior cortical atrophy.