This ROS-sensitive influx of Ca2+ mobilized lysosomal Zn2+ into the mitochondrial matrix, where Zn2+ engaged the small GTPase, dynamin-related protein-1 (Drp-1), to promote mitochondrial fission and, therefore, compromise mitochondrial functioning [300], which is a hallmark of diabetes [8,228]. The gene discussed is DNM1L; the disease is diabetes mellitus.