An insightful investigation conducted on a mouse model of PAH revealed that, although TRPV4 protein is not upregulated in lung microvascular endothelial cells, mitochondrial-derived ROS enhance TRPV4-mediated extracellular Ca2+ entry, thereby boosting endothelial cell proliferation and migration [31]. Here, TRPV4 is linked to pulmonary arterial hypertension.