Quercetin also regulates apoptosis and autophagy-related pathways and facilitates gemcitabine (an analog of deoxycytidine for DNA synthesis inhibition) chemosensitivity through the receptor involved in advanced glycation end products (RAGE)/PI3K/AKT/mTOR axis in human pancreatic cancer cells. The gene discussed is AKT1; the disease is familial pancreatic carcinoma.