However, resistance to EPI becomes a great challenge in treating bladder cancer because it induces cytoprotective autophagy in bladder cancer cell lines T24 and BIU87 via the activation of JNK-mediated phosphorylation of Bcl-2 and disruption of the Bcl-2/Beclin1 complex [198]. This evidence concerns the gene MAPK8 and urinary bladder carcinoma.