Furthermore, co-treatment of NSCLC cells with celastrol and erastin, which are ferroptosis inducers, initiates ATG5/ATG7-dependent autophagy and PINK1/Parkin-dependent mitophagy via the generation of ROS, the disruption of MMP and the promotion of mitochondrial fission [278]. The gene discussed is ATG5; the disease is non-small cell lung carcinoma.