Martine-derived MASM, a potent derivative of matrine, possesses potency against cancer cells by inducing autophagy and apoptosis through ROS-mediated PI3K/AKT/mTOR and the extracellular signal-regulated kinase1/2 (ERK1/2)/p38 signaling pathway in epithelial cancer cell lines [91]. The gene discussed is AKT1; the disease is cancer.