ALK and autosomal dominant macrothrombocytopenia: TPM4 has been associated with inflammatory myofibroblastic tumour and autosomal dominant macrothrombocytopenia (prevalence: <1/1,000,000 worldwide), even if in this case, the association is due to the presence of TPM4-ALK and ALK-TPM3 translocations, resulting in the formation of a fusion gene and transcript, leading to a function different from the physiological TPM4 function [70].